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2007•The Journal of Medical Theory and PracticeRequires access

Expression and Prognostic Significance of Vascular Endothelial Cell Growth Factor(VEGF) in Bladder Transitional Cell Carcinoma

Wang Cui-me

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Abstract

Objective:To study the expression and prognostic significance of VEGF in bladder transitional cell carcinoma(BTCC).Methods:Immunohistochemistry was used to detect the expression of VEGF in BTCC(n=45) and normal bladder mucosa(n=10).Effect was analyzed by both clinical and pathologic data.Results:The positive expression of VEGF in BTCC was 62.22%(28/45),and normal bladder mucosa had no expression.The expression of VEGF was increased with the pathologic grade(grade Ⅰ35.2%,grade Ⅱ71.43%,grade Ⅲ85.71%).There was signifcante difference in the expression of VEGF between grade T2~T4(79.17%) and Tis~T1(42.86%)(P0.05).Conclusion:The expression of VEGF in BTCC is related to the cell differentiation,and it can be a marker of determining prognosis of BTCC.

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What this paper is about

Objective:To study the expression and prognostic significance of VEGF in bladder transitional cell carcinoma(BTCC).Methods:Immunohistochemistry was used to detect the expression of VEGF in BTCC(n=45) and normal bladder mucosa(n=10).Effect was analyzed by both clinical and pathologic data.Results:The positive expression of VEGF in BTCC was 62.22%(28/45),and normal bladder mucosa had no expression.The expression of VEGF was increased with the pathologic grade(grade Ⅰ35.2%,grade Ⅱ71.43%,grade Ⅲ85.71%).There was signifcante difference in the expression of VEGF between grade T2~T4(79.17%) and Tis~T1(42.86%)(P0.05).Conclusion:The expression of VEGF in BTCC is related to the cell differentiation,and it can be a marker of determining prognosis of BTCC.

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Available abstract

Objective:To study the expression and prognostic significance of VEGF in bladder transitional cell carcinoma(BTCC).Methods:Immunohistochemistry was used to detect the expression of VEGF in BTCC(n=45) and normal bladder mucosa(n=10).Effect was analyzed by both clinical and pathologic data.Results:The positive expression of VEGF in BTCC was 62.22%(28/45),and normal bladder mucosa had no expression.The expression of VEGF was increased with the pathologic grade(grade Ⅰ35.2%,grade Ⅱ71.43%,grade Ⅲ85.71%).There was signifcante difference in the expression of VEGF between grade T2~T4(79.17%) and Tis~T1(42.86%)(P0.05).Conclusion:The expression of VEGF in BTCC is related to the cell differentiation,and it can be a marker of determining prognosis of BTCC.

Key concepts: Medicine, Immunohistochemistry, Vascular endothelial growth factor, Transitional cell carcinoma, Clinical significance, VEGF receptors, Bladder Neoplasm, Pathology

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Expression and Prognostic Significance of Vascular Endothelial Cell Growth Factor(VEGF) in Bladder Transitional Cell Carcinoma — Research Paper | ScholarLens