Effect of amlodipine and benazepril combined therapy on renal function in patients with essential hypertension

Objective To examine the effect of amlodipine and benazepril on renal function in patients with essentialhypertension (EH). Methods Sixty six cases with EH were randomly divided into three groups: amlodipine group (5 mgqd, n=22), benazepril group (10 mg qd, n=22) and combined treatment group (amlodipine 5 mg qd+ benazepril 10mgqd, n=22). Treatment lasted for 24 weeks. Parameters of renal function were measured before and after treatment.Results After treatment, urinary total protein and albumin significantly decreased in all the three groups (P0.01).The decrease extent in the combined treatment group was higher than that in the amlodipine and benazepril groups (P0.01), while no significant difference was found between amlodipine and benazepril groups (P 0.05). Combinedtreatment and benazepril alone also significantly increased the glomerular filtration rate (P0.05), but no significantchange was observed in the amlodipine group (P0.05). No significant correlation between the decrease extent of urinaryalbumin and that of SBP or DBP was found among all the three groups (P0.05). Conclusion The data suggested thatamlodipine combined with benazepril treatment should has additive effect on the decrease of urinary albumin excretionand protection of renal function.