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2010•Journal of Foshan UniversityRequires access

Clinical study on HBV infection and intrauterine vertical transmission

Luo Hong-tao

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Abstract

Objective To study the relationship between HBV infection and HBV intrauterine vertical transmission from pregnant women to feotus.Methods 120 women with positive HBsAg who have received pre-natal examination and their full-term babies born between March 2007 and November 2009 in Foshan No.1 People's Hospital were chosen to test their HBV serological markers and HBV-DNA level.Results 12.4% of the 120 newborns were infected.Positive HBsAg,HBsAg and HBV-DNA of newborns within 24 hours were 14.2%,15.8% and 5.0% respectively.Positive HBeAg and HBeAg of the newborns whose mother and positive HBeAg were higher than those whose mothers had negative HBeAg(P0.05).The HBV intrauterine infection of newborns increases as HBV-DNA level rises which indicating that there was a close relation between the infection and HBV-DNA.Conclusion Positive HBeAg and/or high level HBV-DNA were dangerous factors of HBV intrauterine vertical transmission.

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What this paper is about

Objective To study the relationship between HBV infection and HBV intrauterine vertical transmission from pregnant women to feotus.Methods 120 women with positive HBsAg who have received pre-natal examination and their full-term babies born between March 2007 and November 2009 in Foshan No.1 People's Hospital were chosen to test their HBV serological markers and HBV-DNA level.Results 12.4% of the 120 newborns were infected.Positive HBsAg,HBsAg and HBV-DNA of newborns within 24 hours were 14.2%,15.8% and 5.0% respectively.Positive HBeAg and HBeAg of the newborns whose mother and positive HBeAg were higher than those whose mothers had negative HBeAg(P0.05).The HBV intrauterine infection of newborns increases as HBV-DNA level rises which indicating that there was a close relation between the infection and HBV-DNA.Conclusion Positive HBeAg and/or high level HBV-DNA were dangerous factors of HBV intrauterine vertical transmission.

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Available abstract

Objective To study the relationship between HBV infection and HBV intrauterine vertical transmission from pregnant women to feotus.Methods 120 women with positive HBsAg who have received pre-natal examination and their full-term babies born between March 2007 and November 2009 in Foshan No.1 People's Hospital were chosen to test their HBV serological markers and HBV-DNA level.Results 12.4% of the 120 newborns were infected.Positive HBsAg,HBsAg and HBV-DNA of newborns within 24 hours were 14.2%,15.8% and 5.0% respectively.Positive HBeAg and HBeAg of the newborns whose mother and positive HBeAg were higher than those whose mothers had negative HBeAg(P0.05).The HBV intrauterine infection of newborns increases as HBV-DNA level rises which indicating that there was a close relation between the infection and HBV-DNA.Conclusion Positive HBeAg and/or high level HBV-DNA were dangerous factors of HBV intrauterine vertical transmission.

Key concepts: HBeAg, HBsAg, Medicine, Transmission (telecommunications), Serology, Hepatitis B virus, Virology, Obstetrics

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