HEPATITIS B INFECTION IN PREGNANT WOMEN AND NEONATAL HEPATITIS B MARKERS DETECTION

[Objective] To understand the situation of the infection rate between hepatitis B virus markers(HBV-M) positive maternal and hepatitis B virus(HBV) neonatal intrauterine in our city,and provide evidences to cut off the infective access from mother to baby effectively.[Methods] Retrospective investigation was performed on 336 HBV-M positive pregnant women and infants in our hospital,and the pregnant women were divided into three groups based on the infectious level.Then we compared the different infectious levels on the HBV-M.[Results] ① The types of HBV-M between mother and neonate showed to be difference,for example:positive Anti-HBS,HBeAg and Anti-HBC,and positive HBeAg and anti-HBc presented among neonate which rarely occurred in clinical;② The infection rate of neonate born from HBsAg-positive puerperae was 10.2%,meanwhile,the HBV-M-positive(except the single Anti-HBS) rate was 97.3%.Among them,the rate was 35.0%(14/40) caused by HBsAg,HBeAg and Anti-HBc pregnant,then the rate of HBV-M positive was 92.5%(37/40),which mainly included HBeAg-positive.③ The ratio of infected infants whose mother were HBsAg-negative was only 0.5%,however,the positive reached to 88.4%.Furthermore,the same pattern of the puerperae appeared to be most.[Conclusion] The survey indicated that HBsAg-positive with HBeAg-positive would result in high infective risk of intrauterine,at the same time,there also be a high rate with HBsAg-negative so that we shouldn't under-estimate the risk of HBV's spread in intrauterine.