[Study on influence factors of HBV intrauterine infection in newborns of pregnant women with HBsAg].

OBJECTIVE: To explore the interrelated influence factors of HBV intrauterine infection in newborns of pregnant women with HBsAg. METHODS: HBsAg positive pregant women,who were prenatal diagnosis and partal, and their newborns were as subjects. Data of general situation of pregnant women and HBIG Jection history before delivery and HBV infection history in family and HBVM and HBVM in newborns at birth within 24h were collected. By if newborns occurred HBV intrauterine infection, 379 cases HBsAg-positive pregnant women are divided into two groups: 36 cases of HBV intrauterine infection, 343 cases of no HBV intrauterine infection. Then the relationship between the general situation of pregnant women, HBV infection history in family, the state of HBV replication, HBIG injection history, HBVM positive modes and HBV intrauterine infection in newborns were analyzed. RESULTS: Single factors analysis show: The difference of age, the state of HBV replication, HBVM positive modes of HBsAg positive pregant women between HBV intrauterine infection group and no HBV intrauterine infection group is significant (p < 0.05). But cultural levels,HBV infection history in family and HBIG injection history of HBsAg positive pregant women between the two groups isn't significant (p > 0.05). Multiariate Logistic regression analysis display: the age (OR = 0.398, 0.159-0.996) and both postitivity of HBeAg and HBV DNA (OR = 2.539,1.233- 5.227) go into regression equation. Meanwhile, the analysis of relation of HBV DNA load grade of HBsAg positive pregnant women and HBV intrauterine infection show: the different is significant (chi2 = 10.983, P = 0.004 < 0.05); and the analysis of trend chi-quare test show: when HBV DNA copy number is more than 10(6), the rate of HBV intrauterine infection obviously rise. CONCLUSIONS: The age (> 30 years) are the protected factors of HBV intrauterine infection in HBsAg positive pregant women. But when HBsAg positive pregant women is both postitivity of HBeAg and HBV DNA, the possibility is bigger to occur HBV intrauterine infection.