Clinical analysis of HBV vertical transmission

Objective: To discover the clinical factors influencing HBV vertical transmission through analyzing the clinical data of gravida with HBV infection.Methods: Seven hundred and eleven pregnant women with HBV infection,who gave birth in obstetric department of the third affiliated hospital of SUN Yat-sen University were involved.Their clinical data such as HBV DNA level,obstetric situation,lactation situation and whether their babies acquired HBV infection were retrospectively analyzed and compared between HBeAg-positive gravida and HBeAg-negative gravida.Results: No statistical differences were found in age,gestational week,gravidity,parity,threatened abortion,threatened premature delivery,premature rupture of membrane,modes of delivery,spouse HBsAg positive rate,newborn weight and gender between the two groups.However,significant differences existed in HBV DNA level,abnormal liver function during pregnancy,intramuscular administration of HBIG during pregnancy,newborn HBsAg positive and(or)HBV DNA positive rate and the number of babies acquiring HBV infection between the two groups.The rate of HBV vertical transmission was 0.84%.When maternal HBV DNA level was no less than 1011 copies/L,the relative risk of vertical transmission was 20.Conclusion: HBeAg-negative gravida had no vertical transmission.The higher HBV DNA level is,the grater the risk of vertical transmission is.