Comparative analysis between ziprasidone and risperidone in treatment of schizophrenia

Objective:To explore the efficacy and safety of ziprasidone in treatment of schizophrenia.Method:80 patients with schizophrenia were randomly assigned to two groups,ziprasidone group(n=40)and resperidone group(n=40)for 8 weeks.Positive and negative syndrome scale(PANSS)and treatment emergent side effect scale(TESS)were used to evaluate the efficacy and side effects respectively.Results:The response rate and marked response rate in patients of ziprasidone group were 65.0% and 85.0% after 8 weeks,similar to risperidone group.Both the total PANSS scores and factor scores decreased significantly after treatment in two groups(67.5% and 87.5%).However,there were no significant differences between two groups.Total incidence of side effects in ziprasidone group was significantly lower than that in risperidone group.Conclusion:Ziprasidone has a better efficacy in treatment of schizophrenia,which is as effective as resperidone and has fewer side effects compared with risperidone.