A comparative study between ziprasidone and resperidone in treatment of schizophrenia

Objective:To compare the efficacy and safety of ziprasidone and resperidone in the treatment of schizophrenia. Method:Eighty-four patients with schizophrenia were randomly assigned to two groups treated with ziprasidone or risperidone for 8 weeks.The positive and negative symptom scale(PANSS)and treatment emergent symptoms scale(TESS)were used to evaluate the efficacy and adverse effects before and at the end of 2nd,4th,8th weeks of treatment. Results:The total effective rates of ziprasidone and risperidone were 90.5% and 92.5% respectively after 8 weeks treatments.There was no significant difference between two groups(P0.05).Incidence of adverse effects in ziprasidone group(38.1%) was lower than that in risperidone group(57.1%).The rates of extrapyramidal symptoms and endocrine change were significantly higher in risperidone group than those in ziprasidone group(P0.05).But these side effects were not serious,and patients often had good tolerance for them. Conclusion:It is suggested that ziprasidone is an effective drug for schizophrenia,with light side effects.