Effects of Anti-depression Treatment on Depression Symptom and Rehabilitation of Neural Function of Patients with Post-stroke Depression

Objective To investigate the effects of anti-depression treatment with fluoxetine on depression symptom and rehabilitation of neural function of patients with post-stroke depression (PSD).Methods 91 patients with PSD were randomly divided into treatment group and control group.Treatment group were treated with fluoxetine while control group with no anti-depression drug.The effect were measured by Hamilton depression rating scale (HAMD),activity of daily living scale (Barthel Index) and nerve functional defect degree.Results The score of HAMD after fluoxetine treatment was lower in treatment group than in control group (P0.01).Nerve functional defect degree and Barthel index were better in treatment group than in control group significantly (P0.05 or P0.01).The therapeutic efficacy in depression symptom and nerve functional defect in treatment group was better than that in control group (P0.001 or P0.05).The side effects of fluoxetine were insomnia,anxiety and nausea.Conclusion Fluoxetine is effective in treatment of PSD and can improve neurological functions.