2006•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access

Meta-analysis of effectiveness of fluoxetine in treatment of post-stroke depression

Jiang Ya-bin

Abstract

AIM: To further investigate the effectiveness and safety of fluoxetine in treatment of post-stroke depression(PSD).METHODS: The effectiveness and safety of fluoxetine in treatment of PSD patients in 13 controlled studies were analyzed by meta-analysis again in order to assess the comprehensively significant differences and effect size(ES).RESULTS:(1)The scores of Hamilton,and degrees of neurological functional defect and Barthel index in PSD patients before and after treatment with fluoxetine had significant difference(P(0.0005)),and ES: dmean(0.8).(2)Improving degrees of depression symptom,neurological functional defect and activity of daily living scale(ADL) between fluoxetine treatment group and control group had significant difference(P(0.0005)),and ES: dmean(0.8).CONCLUSION: Fluoxetine can significantly ameliorate the depression symptom,neurological functional defect and ADL of patients with PSD,and it has few side effects.

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Key concepts: Fluoxetine, Post-stroke depression, Depression (economics), Barthel index, Activities of daily living, Medicine, Significant difference, Stroke (engine)