A study on the expressions of survivin and bcl-2 and their relationships in transitional cell carcinoma of the bladder

Objective To investigate the expressions of survivin and bcl-2 and their relationships in transitional cell carcinoma of the bladder.Methods The expressions of survivin and bcl-2 in 40 cases of transitional cell carcinoma of the bladder were detected with streptavidin-biotin peroxidase(SP) method,with 15 cases of normal bladder specimens as controls.Results Survivin was expressed in 25 of 40(58.149%) cases of bladder carcinoma tissues,and normal bladder specimens did not express survivin(P0.01).The expression of bcl-2 was positively correlated with survivin expression(P0.01).Conclusion Survivin inhibits the apoptosis of the tumor cells and plays an important role in the carcinogenesis and development of the transitional cell carcinoma of the bladder.The expression of survivin is closely associated with the abnormal expression of bcl-2.