The significance of expression of HIF-1α,Survivin,Bcl-2 in bladder cancer tissues and the correlation among them

Objective To investigate the clinical significance of expression of hypoxia inducing factor-1α(HIF-1α),Survivin,Bcl-2 in bladder cancer tissues and the correlation among them.Methods The expressions of HIF-1α,Survivin,Bcl-2 were detected by immunohistochemistry(HP)in 68 cases of transitional cell carcinoma tissues of bladder and 20 cases of normal bladder tissues.Results The expression levels of HIF-1α,Survivin,Bcl-2 in bladder carcinoma tissues were significantly higher than those in normal bladder tissues(P0.05).The expressions levels of HIF-1α,Survivin,Bcl-2 were positively correlated with the pathological grade of bladder cancer(P0.05),and expression levels of HIF-1α,Survivin in recurrent bladder carcinoma tissues were significantly higher than those in primary bladder carcinoma tissues(P0.05).The correlation analysis showed that there was a positive correlation in the expression between HIF-1α and Survivin,and between HIF-1α and Bcl-2(P0.05).Conclusion The expression levels of HIF-1α are increased in bladder cancer tissues,furthermore which increase with the progress of the tumor,its action mechanism maybe that HIF-1α may regulate the expressions of Survivin and Bcl-2 to enhance the effect of anti-apoptosis so as to promote the development of bladder cancer.