The levels of plasma homocysteine in patients with mild cognitive impairment and the effect of folic acid and Vitamin B_(12)

Objective:To explore the level of plasma homocysteine(Hcy) in patients with mild cognitive impairment(MCI) and to observe the intervention role of folic acid and VitB12 to hyperhomocysteinemia.Method:Fluorescence polarization analyse and microparticle enzyme immunoassay were respectively applied to determine plasma Hcy level and plasma folic acid and VitB12 levels in 80 patients with MCI(MCI group),78 healthy people were as controls(control group).Forty-seven cases with hyperhomocysteinemia were choosed from MCI group and randomly divided into treatment group and non-treatment group according to whether they had received folic acid and VitB12 treatment or not.The level of plasma Hcy and mini-mental state examination(MMSE) score were observed before and after treatment.Result:In MCI group plasma Hcy level was higher than that in control group(P0.05),and plasma folic acid and VitB12 levels were lower than that in control group(P0.05).After treatment with folic acid and Vit B12 plasma Hcy level in treatment group decreased compared with before treatment(P0.05) and was lower than non-treatment group(P 0.05).After treatment MMSE scores in treatment group increased than that before treatment,but there was no significant difference(P0.05).After treatment there was no significant difference of MMSE scores between treatment group and non-treatment group(P0.05).Conclusion:In MCI patients especially in hyperhonocysteinemia level of plasma Hcy is higher and levels of folic acid and VitB12 are lower;level of plasma Hcy could be reduced by adding folic acid and Vit B12.