Therapeutic effect of oxymarrine injection on chronic hepatitis B

Objective To observe the therapeutic effect of oxymarrine injection on chronic hepatitis B. Methods 58 patients with chronic hepatitis B were randomly divided into two groups. 30 patients in treatment group were treated by oxymarrine injection;28 patients in control group were treated by compound Yiganling tablets and routine western medicines, with a treatment course of three months for both groups. The recuperation rate of ALT and negative-conversion rate of HbeAg and HBV-DNA were measured after treatment. The biopsy of liver tissue in 19 patients of treatment group was performed and observed by Knodell score method before and after treatment. Results ZAfter 3-month's treatment the recuperation rate of ALT and negative-conversion rate of HBeAg and HBV-DNA in treatment group were 53.3%,40.0% and 46.7% respectively, which were 25.0%,7.1% and 7.1% in control group respectively. There were significant differences between two groups (P0.05,P0.01,P0.01).After treatment the pathological changes in liver tissue of 19 patients in treatment group were obviously relieved (P0.05),however, the improvement of portal inflammation was not obvious (P0.05). Conclusion The oxymarrine injection has advantages in the treatment of chronic hepatitis B,such as in the improvement of pathological changes of liver tissue, the recuperation rate of ALT and negative-conversion rate of HBeAg and HBV-DNA.