Distribution and antibiotic resistance of pathogen isolated from mid-stream urine of 354 patients

Objective To analyze the distribution and antimicrobial resistance of pathogenic bacteria in urinary tract infection(UTI) so as to provide evidence for appropriate selection of antimicrobial agents in clinical practice.Methods 354 strains of pathogenic bacteria isolated from urine samples were evaluated by the system of Bio-Merieux VITEK COMPACT 2.Drug susceptibility test was performed with the agar dilution method,and ESBLs were detected by double paper phenotype corroborate test.Results Among 354 strains of pathogenic bacteria,most of them were gram-negative bacilli,accounting for about 80.79%,of which predominant strains was Escherichia coli(55.08%).The predominant strain of gram-positive bacteria was Enterococcus faecium,accounting for 4.24%.All of 195 strains of Escherichia coli were sensitive to imipenem,but to other antimicrobial agents show the different degree resistant rates.ESBLs had detected in 108 strains of Escherichia coli,the detection rates for 55.38%.Drug susceptibility of enterococcus faecium to high concentration gentamycin and high concentration streptomycin respectively was 100.0%and 93.3%.Conclusion The predominant bacteria of UTI are still gram-negative bacteria,main of which is Escherichia coli.But gram-positive bacteria has increased in recent years.Bacteria are resistant to a variety of antibiotics.Approximate selection of antibiotics in clinical practice should be made on the basis of susceptibility test results.