Distribution and antimicrobial resistance of 579 strains of pathogenic bacteria isolated from patients with a urinary tract infection

Objective To investigate the distribution and antimicrobial resistance of pathogenic bacteria responsible for urinary tract infections(UTIs).Methods Five hundred and seventy-nine strains of pathogenic bacteria isolated from urine were identified by VITEK 32 from January 2008 to December 2010.Antimicrobial susceptibility testing was performed via a disk diffusion test,and the distribution and antimicrobial resistance of pathogenic bacteria was analyzed with WHONET 5.4.Results Among 579 strains of pathogenic bacteria,the most common was Gram-negative bacilli,the predominant strain of which was Escherichia coli(45.94%).The predominant strains of Gram-positive bacteria were Enterococcus faecalis(12.6%) and Enterococcus faecium(15.0%).The rate of ESBL-producing E.coli,Klebsiella pneumonia,and Proteus mirabilis was 53.00%,36.00%,and 36.59%.The antimicrobial resistance of these pathogenic bacteria differed.Resistance to most antibiotics was greater than 50%,although resistance to cefoperazone-sulbactam,piperacillin-tazobactam,imipenem,meropenem,amikacin,vancomycin,and teicoplanin was relatively low.Conclusion The predominant bacteria from UTIs were Gram-negative bacteria,the most common of which was E.coli.Antibiotics should be used based on results of susceptibility testing.