Analysis on the pathogenic bacteria distribution and drug resistance of urinary tract infection

Objective To research the distribution of common pathogenic bacteria and their drug resistance of urinary tract infection in this hospital for guiding clinical use of antibacterial agents.Methods Pathogenic bacteria isolated from the germiculture positive specimens of midstream urine from Jan.2007 to Dec.2010 in our hospital were retrospective summarized.The species and percentage of the pathogenic bacteria,the drug resistance of main gram-negative bacteria and gram-positive bacteria in common antibacterial agents were analyzed every year.Results 1 525 strains pathogenic bacteria were isolated from the germiculture positive specimens totally,with 1 032 strains of gram-negative bacteria(67.6%),223 strains of gram-positive bacteria(14.6%),270 strains of fungi(17.7%).The main pathogenic bacteria were 645 strains of Escherichia coli(42.3%),117 strains of Klebsiella pneumoniae(7.7%),110 strains of pseudomonas aeruginosa(7.2%),105 strains of Candida albicans(6.9%),92 strains of Enterococcus faecalis(6.0%),79 strains of Candida glabrata(5.2%),and 42 strains of Enterococcus faecium(2.8%).361 strains of Escherichia coli and 57 strains of Klebsiella pneumoniae produced ESBL were detected out,with the enzyme production rates of 56.0% and 48.7%.The antimicrobial susceptibility test results showed that the drug resistance of the pathogenic bacteria was in a very serious situation.Conclusion Gram-negative bacteria is the main pathogenic bacteria of urinary tract infection.Fungal infections is in a rising trend,and the drug resistance of the pathogenic bacteria is in a very serious situation.It should pay more attention to monitor the pathogenic bacteria and their drug resistance,which is important to guide clinic make use of antibacterial agents exactly,control the spread of the drug-resistant strains and nosocomial infection.