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Relationship between transferring,β_2-microglobulin and microalbminuria in patients with diabetic nephropathy

Jing Liang

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Abstract

Objective To discuss the relationship between transferrin(UTRF),β2-microglobulin(β2-MG)and microalbminuria(mALB)in patients with diabetic nephropathy.Methods Immunoturbidimetry assay was applying to measuring urine β2-MG,mALB and UTRF.Results Significantly positive correlations were observed between UTRF and β2-MG(F=0.215,P0.01),mALB and UTRF(F=-0.324,P0.01),as well as UTRF and β2-MG(F=0.161,P0.05).Single factor linear regression analysis showed that UTRF was a related factor of mALB and β2-MG(P0.05).Conclusion mALB and β2-MG were elevated in diabetic nephropathy patients with increasing UTRF.Combined determination of UTRF,mALB and β2-MG may be used as a sensitive and ideal method for estimation of glomerular filtration rate during the early kidney damage in patients with diabetic nephropathy.

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Objective To discuss the relationship between transferrin(UTRF),β2-microglobulin(β2-MG)and microalbminuria(mALB)in patients with diabetic nephropathy.Methods Immunoturbidimetry assay was applying to measuring urine β2-MG,mALB and UTRF.Results Significantly positive correlations were observed between UTRF and β2-MG(F=0.215,P0.01),mALB and UTRF(F=-0.324,P0.01),as well as UTRF and β2-MG(F=0.161,P0.05).Single factor linear regression analysis showed that UTRF was a related factor of mALB and β2-MG(P0.05).Conclusion mALB and β2-MG were elevated in diabetic nephropathy patients with increasing UTRF.Combined determination of UTRF,mALB and β2-MG may be used as a sensitive and ideal method for estimation of glomerular filtration rate during the early kidney damage in patients with diabetic nephropathy.

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Available abstract

Objective To discuss the relationship between transferrin(UTRF),β2-microglobulin(β2-MG)and microalbminuria(mALB)in patients with diabetic nephropathy.Methods Immunoturbidimetry assay was applying to measuring urine β2-MG,mALB and UTRF.Results Significantly positive correlations were observed between UTRF and β2-MG(F=0.215,P0.01),mALB and UTRF(F=-0.324,P0.01),as well as UTRF and β2-MG(F=0.161,P0.05).Single factor linear regression analysis showed that UTRF was a related factor of mALB and β2-MG(P0.05).Conclusion mALB and β2-MG were elevated in diabetic nephropathy patients with increasing UTRF.Combined determination of UTRF,mALB and β2-MG may be used as a sensitive and ideal method for estimation of glomerular filtration rate during the early kidney damage in patients with diabetic nephropathy.

Key concepts: Diabetic nephropathy, Medicine, Renal function, Internal medicine, Beta-2 microglobulin, Nephropathy, Endocrinology, Transferrin

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Relationship between transferring,β_2-microglobulin and microalbminuria in patients with diabetic nephropathy — Research Paper | ScholarLens