Characteristic of Pramary Hyperuricemia in Male and Association between Serumuric Acid Level and Components of the Metabolic Syndrome

Objective To evaluate the clinical and biochemical characteristics of male patients with pramary hyperuricemiaand to investigate the association between serum uric acid and the components of metabolic syndrome.Methods In the cross-sectional study of 1017 males,we recorded body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),and collected blood samples to measure serum uric acid(UA),blood lipide profile(triglyceride(TG),high-density cholesterol(HDL-C),totalcholesterol(TC),fasting plasma glucose(FPG),urea nitrogen(BUN) and creatinine(Cr).Results(1)The hyperuricemia group had higher prevalence of obesity,hypertension and dyslipidemia than the normal-uricemia group.There was no significant difference in the prevalence of impaired free glucose between the two groups.(2)According totheir possession of 0,1,2,3 or 4 components of metabolic syndrome,1017 cases were divided intofive groups(MS0,MS1,MS2,MS3 and MS4).There were significant differences in the levels ofUA.(3)Men with hyperuricemia had significantly increased levels of BMI,DBP,TG,TC,BUN and Cr,decreased level of HDL-C as compared with those without hyperuricemia.There were no significant differences in the levels of SBP and FPG between thetwo groups.(4)Multiple regression analysis showed that UA concentration was positively correlated with age,BMI,TG,TC and Cr.Conclusion Pramary hyperuricemia in male was positively associated with metabolic syndrome;Blood glucose;Blood-Lipid.