2008•Zhongguo yaofangRequires access

Permeation Enhancing Effect of Flos Caryophylli Volatile Oil Versus Azone on Diclofenac Sodium

Chen Guang-bin, Jiantao Lin

Abstract

OBJECTIVE:To evaluate the permeation enhancing effect of Flos Caryophylli volatile oil versus azone on diclofenac sodium.METHODS:Percutaneous absorption experiment was performed on the apparatus of isolated skin,and the penetrated amounts of diclofenac sodium at different time were measured,then the steady-state flux and enhancing rate were calculated,and the deposit effect of diclofenac sodium was investigated.RESULTS:Flos Caryophylli volatile oil and azone all had promotion effect on percutaneous absorption of diclofenac sodium,especially when they used in combination.Used either in combination or alone,they all had remarkable enhancement property on deposit effect of diclofenac sodium(P0.05 or P0.01).CONCLUSION:Flos Caryophylli volatile oil is expected to become a skin penetration enhancer for its relative powerful promotion effect.

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Key concepts: Azone, Flos, Diclofenac Sodium, Chemistry, Chromatography, Diclofenac, Permeation, Penetration (warfare)