Effects of Several Penetration Enhancers on in vitro Percutaneous Transport of Diclofenac Sodium in Cataplasm

The effects of different concentrations of several penetration enhancers,such as azone,oleic acid, borneol,menthol and Tween-80,on in vitro percutaneous transport of diclofenac sodium in cataplasm through excised mouse skin were investigated with enhancing rate and lag time as indicators by an improved Franz diffusion cell. Compared with blank control group,the enhancing rates of 1%azone,3%oleic acid,1%borneol,3%menthol and 1%Tween-80 were 1.26,2.99,3.10,3.31 and 0.94 with the lag time of 3.30,0.33,0.15,0.04 and 1.25 h,respectively.The results showed that 1%Tween-80 had no significant permeation enhancement effect.The enhancing effects of oleic acid, borneol and menthol on percutaneous transport of diclofenac sodium were better than that of azone as well as the lag time was shortened.