Influence of the volatile oil from cablin patchouli herb on the transdermal kinetic of diclofenac sodium

Objective To determine the enhancing effect of the volatile oil from cablin patchouli herb on the transdermal absorption of diclofenac sodium.Methods The transdermal absorption of diclofenac sodium was carried on intact rat skin and on the stratum corneum removed skin respectively pretreated with the volatile oil from cablin patchouli herb and Azone for 12 hours.The concentration of diclofenac sodium in transdermal perfusate was detected at different intervals.The cumulate penetrated amount,penetrating rate and stable flux were calculated.Results The volatile oil from cablin patchouli herb and Azone can enhance the percutaneous absorption of diclofenac sodium,but the effect of the volatile oil from cablin patchouli herb on diclofenac sodium was significantly different with that of azone(P 0.05).The lag time of Azone was shorted,and the lag time of the volatile oil from cablin patchouli herb was lengthened.The two permeation enhancers in the intact skin could not decrease the deposit effect of diclofenac sodium.The two permeation enhancers in the treated skin whose stratum corneum removed could decrease the deposit effect of diclofenac sodium.Conclusion The volatile oil from cablin patchouli herb promotes the percutaneous absorption of diclofenac sodium.