Expression of P16 in gastric cancer and its correlation with prognosis

Purpose:To study the expression of multiple tumor suppressor 1 (MTS1) gene products in gastric cancer and its correlation with clinicopathologcal indicators and prognostic significance. Methods:MTS1 gene products were observed in 65 gastric cancers, 10 normal gastric tissues and 35 non cancerous tissues with LSAB immunohistochemical methods.Results:The positive expression rates of P16 was lower in gastric cancer than that in the normal gastric tissues and non cancerous gastric disease tissues ( P 0 05). Expression of MTS1 gene products was positively related to the degree of differentiation, it was negatively related to invasive depth and lymph node metastasis, Patients with positive expression of P16 had higher 3 year survival rate than those with negative P16. Conclusions:MTS1 may play a role in the development of gastric cancer, and was partially related to biological behavior. Expression of P16 protein may serve as an important molecular biological indicator of diagnosis and prognosis of gastric cancer.