2012•Clinical ophthalmologyOpen access

Expression and function of Bcl-2 、MMP-9 and Ki67 in pterygium

Yang Gui-fan, Cai Xiao-ju

Abstract

Objective To study the expression and the relationship of B-cell lymphoma/leukemia-2(Bcl-2),matrix metalloproteinases-9(MMP-9) and Ki67 in pterygium,and the relationship of pterygium and tumor.Methods The expression of Bcl-2,MMP-9 and Ki67 were detected in 76 cases with pterygium by immunohistochemical method and were compared with the normal conjunctiva epithelium in other 9 cases.Result The expression of Bcl-2,MMP-9 and Ki67 were higher in pterygium than in normal conjunctiva epithelium(P0.05).The expression of Bcl-2 was related to that of MMP-9.Conclusion The increase of Bcl-2 and MMP-9 are presented in pterygium,which may play an important role in the origin and development of pterygium.Pterygium has some relationgship with tumor.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Pterygium, Conjunctiva, Medicine, Matrix metalloproteinase, Immunohistochemistry, Pathology, Epithelium, Ophthalmology