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2012•Chinese Journal of Aesthetic MedicineRequires access

Expression and clinical significance of MMP-2 and Ki-67 in Pterygium

GU Qiu-yan

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Abstract

Objective To investigate the expression of matrix metalloproteinase-2(MMP-2) and Ki-67 in pterygium tissues and its clinical significance.Methods The expression of MMP-2 and Ki-67 were determined by immunohistochemistry in 39 cases of primary pterygium and 12 cases of normal conjunctiva.Results The expression of both MMP-2 and Ki-67 in pterygium tissues were significant higher than that in normal conjunctiva(Z=-3.044,Z=-2.707 respectively,both P0.05).Conclusion The high level of MMP-2 and Ki-67 in pterygium sugested that catabolism of basal membrane and cell proliferation were abnormal,which may play an important role in the development of pteryguim.

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Objective To investigate the expression of matrix metalloproteinase-2(MMP-2) and Ki-67 in pterygium tissues and its clinical significance.Methods The expression of MMP-2 and Ki-67 were determined by immunohistochemistry in 39 cases of primary pterygium and 12 cases of normal conjunctiva.Results The expression of both MMP-2 and Ki-67 in pterygium tissues were significant higher than that in normal conjunctiva(Z=-3.044,Z=-2.707 respectively,both P0.05).Conclusion The high level of MMP-2 and Ki-67 in pterygium sugested that catabolism of basal membrane and cell proliferation were abnormal,which may play an important role in the development of pteryguim.

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Available abstract

Objective To investigate the expression of matrix metalloproteinase-2(MMP-2) and Ki-67 in pterygium tissues and its clinical significance.Methods The expression of MMP-2 and Ki-67 were determined by immunohistochemistry in 39 cases of primary pterygium and 12 cases of normal conjunctiva.Results The expression of both MMP-2 and Ki-67 in pterygium tissues were significant higher than that in normal conjunctiva(Z=-3.044,Z=-2.707 respectively,both P0.05).Conclusion The high level of MMP-2 and Ki-67 in pterygium sugested that catabolism of basal membrane and cell proliferation were abnormal,which may play an important role in the development of pteryguim.

Key concepts: Pterygium, Conjunctiva, Matrix metalloproteinase, Immunohistochemistry, Clinical significance, Basal (medicine), Ki-67, Pathology

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