Application of dezocine combined with flurbiprofen axetil in analgesia of patients with liver dysfunction after cesarean section

Objective: To observe the effect of dezocine combined with flurbiprofen axetil in patient- controlled intravenous analgesia( PCIA) of patients with liver dysfunction after cesarean section. Methods: A total of 120 patients with liver dysfunction after elective cesarean section were selected and randomly divided into three groups,40 patients in each group,all the patients in the three groups were treated with PCIA; the drugs used in group A,group B,and group C were fentanyl 0. 5 mg + flurbiprofen axetil 250 mg,dezocine 30 mg + flurbiprofen axetil 250 mg,flurbiprofen axetil 250 mg; the patients in the three groups were treated with ondansetron 16 mg( diluted to 100 ml with normal saline),the initial load dosage was 2 ml,the continuous dose was 2 ml / h,the single dose of PCIA was 0. 5 ml,the treatment time was 15 minutes; VAS scores,times of PCIA within 24 hours after treatment,and adverse reactions at 2,4,8,24,48 hours after treatment were observed and recorded. Results: VAS scores in group C at different time points after treatment were statistically significantly higher than those in group A and group B( P 0. 05),but there was no statistically significant difference between group A and group B( P 0. 05); the times of PCIA within 24 hours after treatment in group C was( 16. 1 ± 1. 3) times,which was statistically significantly higher than those in group A 〔( 10. 8 ± 1. 8) times〕and group B 〔( 11. 0 ± 1. 6) times〕( t = 3. 54,P 0. 05; t = 3. 98,P 0. 05); no adverse reactions occurred in the three groups,such as respiratory depression,abnormal bleeding; the total incidence rate of adverse reactions in group A was 37. 5%,which was statistically significantly higher than those in group B( 12. 5%) and group C( 10. 0%)( P 0. 05). Conclusion: Dezocine combined with flurbiprofen axetil can be used for analgesia of patients with liver dysfunction after cesarean section safely and effectively.