Clinical Research of Flurbiprofen Axetil Combined with Fentanyl for Patient-controlled Venous Analgesia after Postoperative of Thoracoabdominal Injury

Objective To observe the clinical effects of flurbiprofen axetil combined with fentanyl for patient-controlled venous analgesia after postoperative of thoracoabdominal injury.Methods 84 cases were randomly divided into fentanyl group(group A),flurbiprofen axetil group(group B),flurbiprofen axetil combined with high-dosage fentanyl group(group C) and flurbiprofen axetil combined with low-dosage fentanyl group(group D),with 21 cases in each group.Fentanyl 0.5 mg in group A,flurbiprofen axetil 50 mg in group B,flurbiprofen axetil 50 mg and fentanyl 0.5 mg in group C and flurbiprofen axetil 50 mg and fentanyl 0.5 mg in group D made respectively 100 mL solution plus distilled water.The visual analog scale(VAS),Ramesay score,times of PCIA and incidence of side effects at 3,6,12,24 h after operation were all recorded,and as well as analgesic satisfaction at the end of the observation.Results The VAS and Ramesay scores of group C and D with each time point were slightly fewer than that of group A and B(P 0.05).The incidence of side effects of group C and D were lower than that of the group A and B(P 0.05 or P 0.01).The time of PCIA group C and D was significantly less than group A and group B(P 0.05).Compared with group C,there was no statistically significant difference in VAS and Ramesay score and significantly reduced times of PCIA and incidence of side effects in group D.Conclusions Flurbiprofen axetil combined with fentanyl for patient-controlled venous analgesia has a better analgesic effect than separate application opiates(fentanyl) or nonsteroidal anti-inflammatory drug(lurbiprofen axetil) after postoperative of thoracoabdominal injury,and can obviously reduce the dosage of fentanyl and the incidence of side effects,and improve the treatment of patients with satisfaction.