Flurbiprofen Axetil Combined Dezocine for Thyroid Surgery Postoperative Analgesia

Objective: To study the effect of flurbiprofen ester combined with dezocine on postoperative analgesic in patients with thyroid surgery.Methods: 90 cases of ASA I or class II thyroid surgery included nodular goiter,hyperthyroidism,thyroid cancer.Aged 21-59 years,generally in good condition,were randomly divided into three groups: flurbiprofen axetil dezocine(FD group),flurbiprofen ester(F group),dezocine(D),each30 cases.30 min before the end of surgery,drugs were slow intravenous infused: FD group,flurbiprofen axetil 50 mg + to dezocine 5 mg;F Group,flurbiprofen axetil 50 mg;D Group,dezocine 5 mg.And then patients in each group were pumped into the different drugs: the FD Group,the flurbiprofen axetil 200 mg + dezocine for 30 mg;F group,flurbiprofen axetil 200 mg;group D,dezocine 30 mg,so as tosaline solution was diluted to 100 mL,the rate of continuous infusion was 2 ml / h for 48 hours.Time point of recording was:(T1) after 2 h(T2) after 6 h(T3) after 12 h(T4) after 24 h,48 h after operation(T5),and mean arterialpressure(MAP),heart rate(HR),oxygen saturation(SPO2) and the point in time the pain score(VAS),sedation score(Ramsay),and record the number of cases appears nausea,vomiting,dizziness and other complications were recorded.Results: Hemodynamics in FD and F group were more stable than that in D group,SPO2 in D group had transient drop.The postoperative VAS scorein D group was significantly higher than that in the FD group F(P 0.05),Ramsay score in FD and F group than that in group D(P 0.05).Conclusion: For analgesia in thyroid surgery,flurbiprofen axetil combined with dezocine have fewer complications and a good analgesia,and VAS and Ramsay score are better than that with the simple application of flurbiprofen axetil or dezocine.