PREEMPTIVE ANALGESIA FOR POSTOPERATIVE PAIN RELIEF OF FLURBIPROFEN AXETIL INJECTION ON CHILDREN

Objective: To investigate the safety and efficacy of preemptive analgesia for postoperative pain relief of flurbiprofen axetil injection on children. Methods: 90 children aged from 2 to 5 yr undergoing abdominal surgery were randomly divided into three groups. The patients in group A received post operative analgesia with flurbiprofen axetil injection 0.5 mg/kg after anesthesia and before operation. The patients in group B received post operative analgesia with flurbiprofen axetil injection 0.5 mg/kg after operation. The patients in group C received normal saline. All groups received patient controlled intravenous analgesia (PCIA) in 48 h. In group A and B, PCIA mixture consisting of flurbiprofen axetil injection 1 mg/kg combined with fentanyl 8 μg/kg and add saline to 100 ml. In group C, PCIA mixture consisting of fentanyl 10 μg/kg and add saline to 100 ml. All group received granisetron 3 mg i.v. at the end of the operation. Results: VAS scores in group C were significantly higher than that in group A and in group B (P 0.01). VAS scores in group B were significantly higher than that in group A (P 0.01). Sedation score were no difference among group A, group B and group C (P0.05). There were no difference of the incidence of arrhythmia, respiratory depression, coagulation disfunction, postoperative nausea and vomiting among group A, group B and group C (P0.05). Conclusion: Flurbiprofen axetil injection can offer effective, safer preemptive analgesia for postoperative pain relief in children.