Change and significance of IGFBP-3 in serum and leiomyoma tissue of patients with uterine leiomyoma

Objective To detect the change of insulin-like growth factor binding protein-3(IGFBP-3) in serum and leiomyoma tissue of patients with uterine leiomyoma. Methods The serum IGFBP-3 from 60 cases of uterine leiomyoma and 60 cases healthy women was tested by ELISA,the IGFBP-3 leiomyoma tissue and myometrium tissue from the 60 cases uterine leiomyoma was tested by immunohistochemistry. Results In patients with uterine leiomyoma,the serum IGFBP-3 was significantly lower than that in healthy women,the IGFBP-3 in leiomyoma tissue was significantly weaker than that of normal myometrium,P0.01. Conclusion The IGFBP-3 in both serum and leiomyoma tissue are lower in patients with uterine leiomyoma,which suggests that IGFBP-3 play important role in the occurrence,development of uterine leiomyoma.