Clinical Study on the Effects of Alprosladil and Glutathione Therapy on Patients with Drug-induced Acute Renal Damage

Objective To study the effects of Alprosladil and Glutathione therapy on patients with drug-induced acute renal damage. Methods 108 patients with drug-induced acute renal damage were divided into three groups at random. The patients in gruoup A (n=36) received 10μg Alprosladil injection once a day, the patients in group B (n=42) received both 10μg alprosladi and 1200mg glutathione injection once a day additionally, and the patients in group C (n=30) received 10mg dpamine injection once a day. The course of treatment of the three groups was 2～4 weeks. Results The effective rates for acute renal failure in groups A, B and C were 85 7%, 96% and 61% respectively. The effective rates for proteinuria, hematuria, N-acetyl-β-glucosaminidase(NAG)and retinol-binding protein(RBP) in urine were 70%, 78%, 76% and 80% in group A, 85%, 90%, 90% and 90% in group B, and 50%, 50%, 42% and 58% in group C respectively, which had significant difference among the three groups (P0 05). Conclusion Combination use of alprosladil and glutathione had marked therapeutic effect on drug-induced acut renal damage, while only use of alprosladil had a certain therapeutic effect on it.