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2000•Chinese Journal of New Drugs and Clinical RemediesRequires access

Glutathione in treatment of drug induced acute kidney injury

Wei Cai

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Abstract

AIM: To evaluate the effects of glutathione in treating acute kidney injury resulted from various drugs. METHODS: Eightyeight patients with such disease were divided into two groups, treatment group and control group. Fiftytwo patients of reatment group were given glutathione 1.2 g, iv,gtt, qd×2～4 wk. Some of thirtysix patients of the control group were given compound amino acid injection (9AA) 250 mL, iv,gtt,qd×2～4 wk; the others who had no acute kidney failure were given paecilomyces hepiali chen (Cs4) 0.99 g,tid ×4 wk. RESULTS: For acute kidney failure the total effect rate was 92 % in treatment group and 64 % in control group (P0.05). For hematuria and proteinuria, the total effect rate were 89 % and 85 % in treatment group, 57 % and 50 % in control group (P0.01, P0.05). CONCLUSION: Glutathione has obvious effect for acute kidney injury resulted from various drugs.

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AIM: To evaluate the effects of glutathione in treating acute kidney injury resulted from various drugs. METHODS: Eightyeight patients with such disease were divided into two groups, treatment group and control group. Fiftytwo patients of reatment group were given glutathione 1.2 g, iv,gtt, qd×2～4 wk. Some of thirtysix patients of the control group were given compound amino acid injection (9AA) 250 mL, iv,gtt,qd×2～4 wk; the others who had no acute kidney failure were given paecilomyces hepiali chen (Cs4) 0.99 g,tid ×4 wk. RESULTS: For acute kidney failure the total effect rate was 92 % in treatment group and 64 % in control group (P0.05). For hematuria and proteinuria, the total effect rate were 89 % and 85 % in treatment group, 57 % and 50 % in control group (P0.01, P0.05). CONCLUSION: Glutathione has obvious effect for acute kidney injury resulted from various drugs.

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Available abstract

AIM: To evaluate the effects of glutathione in treating acute kidney injury resulted from various drugs. METHODS: Eightyeight patients with such disease were divided into two groups, treatment group and control group. Fiftytwo patients of reatment group were given glutathione 1.2 g, iv,gtt, qd×2～4 wk. Some of thirtysix patients of the control group were given compound amino acid injection (9AA) 250 mL, iv,gtt,qd×2～4 wk; the others who had no acute kidney failure were given paecilomyces hepiali chen (Cs4) 0.99 g,tid ×4 wk. RESULTS: For acute kidney failure the total effect rate was 92 % in treatment group and 64 % in control group (P0.05). For hematuria and proteinuria, the total effect rate were 89 % and 85 % in treatment group, 57 % and 50 % in control group (P0.01, P0.05). CONCLUSION: Glutathione has obvious effect for acute kidney injury resulted from various drugs.

Key concepts: Glutathione, Medicine, Acute kidney injury, Kidney, Drug, Internal medicine, Proteinuria, Gastroenterology

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