Expression and correlation between Survivin and Bcl-2 in cervical intraepithelial neoplasia and cervical carcinoma

Objective:To investigate the expression of Survivin and Bcl-2 in cervical intraepithelial neoplasia and cervical carcinoma,and to explore the role of them in cervical carcinoma pathogenesis.Methods:The expression of Survivin mRNA was detected with hybridiza-tion in situ in CIN and cervical carcionma,and the expression of Bcl-2 was detected with immunohistochemical method.Normal cervical tissues were acted as the control.Results:The positive rates of Survivin mRNA in cervical carcinoma,CIN and the normal cervical tissues were 77.8%,44.6% and 0%,respectively;while the expression of Bcl-2 was 70.4%,39.2% and 0% in the above three groups.There was significant difference among those groups.The expression of Survivin and Bcl-2 in CINⅢ was obviously more significant than those in CIN I/Ⅱ.And the differences were obviously more significant in cervical carcinoma at stage Ⅱb～Ⅲ than those at stageⅠ～Ⅱa.The expressions of Survivin and Bcl-2 with poorly differentiation were also obviously more significantly different than those with good or moderated differentiation.The expression of Survivin in cervical carcinoma with lymphatic metastasis was more significant difference than those without lymphatic metastasis.In our study,positive correlation between Survivin mRNA and Bcl-2 was observed in cervical carcinoma.Conclusion:The abnormal expression of Survivin and Bcl-2 may participate in the occurrence and development of cervical carcinoma,they may have same effect in coordination with anti-apoptosis,and suggest malignant degree of tumor and patients’poor prognosis.