Clinical study with the method of purging liver and the heart fire,nourishing yin and moistering arid on patients with type 2 diabetes

AIM: To investigate the clinical effect of the treatment of the method of purging liver and the heart fire or nourishing yin and moistering arid, and that of both of them being used together in treating type 2 diabetes mellius, at the same time to evaluate differences of them of improving insulin resistance one by one. METHODS: 120 patients with type 2 diabetes were randomly divided into four groups with 30 cases each. They were treated with the method of purging liver and the heart fire (group 2)、with the methods of nourishing yin and moistering arid (group 3)、both of the two methods (group 1)、the drugs of rosiglitazone 4 mg a day (group 4), each for 1 month. The serum level of resistin、adiponectin、Leptin、TNF-α、CRP、IL-6 were measured of the four groups before and after the treatment by ELISA method, and blood pressure、blood sugar、lipid as well as insulin resistance levels were measured before and after treatment too. RESULTS: After treatment, Four groups could reduce blood sugar, no significant difference was observed between the four groups (P0.05). group 1 and group 4 could significantly reduce the level of lipid、FINS, increase the level of IAI (P0.01), but the group 2 and group 3 affection were not significant (P0.05). After treatment, the clinical symptom score dropped in group 1、2、3 (P0.01 or P 0.05 ), no significant difference was observed in group 4, and it was the lowest in the group 1 in the four groups (P0.01). At the same time, serum levels of CRP decreased in four groups. serum levels of Leptin、TNF-α、IL-6 decreased in group 1、2、4 (P0.01 or P0.05), no difference was observed in group 3 (P0.05); serum levels of resistin decreased and adiponectin increased in group 1、4 (P0.01 or P0.05), no difference was observed in group 2、3 (P0.05). More significant difference was observed in group 1、4 between the four groups about the serum level of resistin、adiponectin、Leptin、TNF-α、CRP、IL-6 (P0.01). And between the group 2 and group 3, the serum level of CRP、Leptin、TNF-α、IL-6 in group 2 were reduced more than group 3, there was difference was observed between the two groups (P0.01 or P0.05). CONCLUSION: The method of purging liver and the heart fire, nourishing yin and moistering arid can improve insulin resistance and alleviate clinical symptoms of Type 2 diabetes mellitus patients, the mechanism may be related to its actions in regulating the production of inflammatory cytokines and inhibiting inflammatory reaction.