Effect of the Yiqi Yangyin Qingre Formula on the inflammatory cytokines in patients with type 2 diabetes mellitus

Objective: To observe the influence of the formula of supplementing Qi,nourishing Yin and clearing heat(Yiqi Yangyin Qingre) on C-reactive protein(CRP),tumor nercrosis factor-α(TNF-α),interleukin 6(IL-6) in patients with type 2 diabetes mellitus.Methods: 200 incipient patients with type 2 diabetes mellitus were selected and randomly divided into treatment group and control group.Both groups were treated by basic treatment,and the treatment group was treated with the formula of SQNYCH,one dose per day,the control group were treated with pioglitazone,30mg per day.The treatment courses of both groups were 4 weeks,and fasting blood glucose(FBG),lipid,hsCRP,TNF-α and IL-6 were measured before and after treatment.Results: After treatment,the FBG of both groups were obviously lower than before treatment(P0.01).The lipid levels of before and after treatment were no significant differences in both groups.After treatment,the levels of TNF-α,IL-6 and CRP were significantly reduced in both groups(P0.01),compared with the control group,the decline was more significant in the treatment group(P0.01);Through the analysis of the relation,positive correlation was found between TNF-α or IL-6 and hsCRP before or after treatment.Conclusion: The SQNYCH formula could effectively lower the levels of the related inflammatory cytokines in the patients with type 2 diabetes mellitus,and there was a positive correlation between TNF-α or IL-6 and CRP.