Effect of Yiqi Yangyin Huoxue Principle on Insulin Resistance And Serum leptin level in Patients with Type 2 Diabetes Mellitus Combined with Fatty liver Disease

Objective:This paper aimed to investigate the efficacies of Yiqi Yangyin Huoxue principle on insulin resistance and abnormal serum leptin/leptin-R level and to discuss the partial mechanism of Yiqi Yangyin Huoxue principle in patients with type 2 diabetes mellitus combined with fatty liver disease.Methods:We selected 96 patients with type 2 diabetes mellitus combined with fatty liver disease who were diagnosed with qiyinliangxu and xueyu by traditional Chinese medical.These patients were grouped into control and experimental group randomly.They all performed basic treatment,like oral antidiabetic drug,diet control as well as more exercise to regulate the blood sugar level,while the patients of experimental group,in addition to the above treatment,were given the Chinese medicine of Yiqi Yangyin Huoxue.The treatment period was 3 months.Liver ultrasound examination and biochemical tests,including lipid,insulin resistance and leptin/leptin-receptor analysis were carried out for those 96 patients before and after the treatment.Result:1.There was no significant difference between the DFL degree of two groups before treatment(P0.05).The DFL degree was reversed to different degrees after the 3-month treatment.The DFL degree of the experimental group was significantly improved(P0.01)while that of the control group was not so significantly improved(P0.05).The DFL degree of the experimental group was significantly better than that of the control group after 3 months(P0.05).2.Insulin resistance level of the two groups were both significantly reduced after the 3-month treatment.The insulin level of the experimental group was reduced more significantly than that of the control group(P0.01).3.The serum leptin/leptin-R level of the control group was not significantly improved(P0.05)but that of the experimental group was significantly improved(P0.01,P0.01)after the treatment.Conclusion: The Yiqi Yangyin Huoxue principle could siginificantly improve the insulin resistance and abnormal serum leptin/leptin-R level of patients with type 2 diabetes mellitus combined with fatty liver disease and this could be one of the main mechanisms of the effects of the Yiqi Yangyin Huoxue principle on type 2 diabetes mellitus combined with fatty liver disease.