The Study of Batroxobin in the Treatment of Coagulation and Fibrinolytic System in Acute Cerebral Infarction

Objective To explore the effects of Batroxobin on coagulation and fibrinolytic system in patients with acute cerebral infarction.Methods The levels of prothombin time(PT), activated partial throm-boplasmin time(APTT), fibrinogen(Fg), D - Dimer were measured in 30 patients before and after treatment with Batroxobin. There are 20 cases in the control group.Results Compared with the contrl group, before treatment PT and APTT levels were significantly decreased,fibrinogen (Fg) and D - Dimer levels were increased (all P 0.05). After treatment PT and APTT were prolonged. Fg levels greatly decreased, D - Dimer levels were significantly increased(all P 0.01) . Conclusions The activity of coagulation system of patients with acute cerebral infarction is higher than that in normal. It is the important reason of thrombus formation. Batroxobin will reduce the coagulation activity and increase the fibrinolytic activity accelerate thrombus dissolving. Coagulation and fibrinolytic system is intermediate link of the whole process. To observe changes of coagulation and fibrinolytic system will have great significance in diagnosis and trreatment.