The effect of S-adenosyl-methionine treatment on drug-induced liver injury

Objective To evaluate the therapeutic efficacy and safety of different dose S-adenosyl-L-methionine on drug-induced cholestasis liver injury and mixed liver injury.Methods a total of 66 patients suffered from drug-induced cholestasis liver injury and mixed liver injury were randomly divided into treatment group and control group.Furthermore,the treatment group was divided into 2 groups as treatment 1 group and treatment 2 group.The control group was treated with common therapy,while the treatment 1 group was treated with S-adenosyl-L-methionin up to 1 g/d as well as the treatment 2 group was treated with S-adenosyl-methionin up to 2 g/d.After 4 weeks of treatment,liver function was measured.Results The level of total bilirubin and alanine transaminase significantly decreased in the treatment group than the control group(P 0.05).Moreover,no adverse reactions were observed.Total bilirubin and alanine transarninase significantly decreased in treatment 2 group compared to treatment 1 group(P 0.01).Conclusion The therapeutic efficacy and safety of large dose S-adenosyl-L-methionin in treating drug-induced cholestasis liver injury and mixed liver injury is better compared to the common therapy.