Effect of S-adenosyl methionine on acute cholestasis hepatitis patients

Objective To evaluate the effect and adverse events of S-adenosyl methionine on acute cholestasis hepatitis patients.Methods Total of 76 patients with acute cholestasis hepatitis were randomly divided into two groups:the control group(29 cases) were intravenously injected with diammonium glycyrrhizinate and Yinzhihuang,while the S-adenosyl methionine therapeutic group(47 cases) were treated with S-adenosyl methionine(1000 mg/d) besides the above medicines.After treatment for 2,4 and 6 weeks,the manifestations changes were estimated and the clinical symptoms,serum parameters of liver function(TBil,ALT,AST,ALP,GGT) and adverse events were detected for both groups.Results After treatment for 2,4 and 6 weeks,descents of serum TBil in the therapeutic group were 46%,77%,92%,respectively,which were 37%,60% and 90% in the control group.Clinical symptoms were improved in both groups.The improvement rate of skin pruritus in therapeutic group(70.0%) was signif icantly higher than that in control group(45.0%).Conclusions S-adenosyl methionine can decrease jaundice rapidly,especially in 4 weeks,also it may improve skin pruritus signif icantly and no serious adverse events were reported.