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2010•Strait Pharmaceutical JournalRequires access

Study on Preparing technique of Baicalin liposomes

WU Da-zhang

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Abstract

OBJECTIVE To study the preparing technique of baicalin liposomes.METHODS Bacalin liposomes were prepared by reverse-phase evaporation,A reasonable criterion of accurate evaluation was established so that the best preparation technology is determined.RESULTS The optimized preparation conditions for baicalin phytosomes were obtained as follows:the ratio of aqueous phase to organic phase was 1 to 4.the dosage of phospholipid was 200mg.The ratio of phospholipid to cholesterin was 1 to 6.Baicalin concentration was 5 mg·mL-1.the mean diameter of liposomes was 178nm,envelopment percentage was 50.3%.RESULTS The optimized preparation is feasible and stable.

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What this paper is about

OBJECTIVE To study the preparing technique of baicalin liposomes.METHODS Bacalin liposomes were prepared by reverse-phase evaporation,A reasonable criterion of accurate evaluation was established so that the best preparation technology is determined.RESULTS The optimized preparation conditions for baicalin phytosomes were obtained as follows:the ratio of aqueous phase to organic phase was 1 to 4.the dosage of phospholipid was 200mg.The ratio of phospholipid to cholesterin was 1 to 6.Baicalin concentration was 5 mg·mL-1.the mean diameter of liposomes was 178nm,envelopment percentage was 50.3%.RESULTS The optimized preparation is feasible and stable.

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Available abstract

OBJECTIVE To study the preparing technique of baicalin liposomes.METHODS Bacalin liposomes were prepared by reverse-phase evaporation,A reasonable criterion of accurate evaluation was established so that the best preparation technology is determined.RESULTS The optimized preparation conditions for baicalin phytosomes were obtained as follows:the ratio of aqueous phase to organic phase was 1 to 4.the dosage of phospholipid was 200mg.The ratio of phospholipid to cholesterin was 1 to 6.Baicalin concentration was 5 mg·mL-1.the mean diameter of liposomes was 178nm,envelopment percentage was 50.3%.RESULTS The optimized preparation is feasible and stable.

Key concepts: Baicalin, Liposome, Chromatography, Chemistry, Aqueous two-phase system, Phospholipid, Phase (matter), Aqueous solution

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