Clinical infection characteristics and drug resistance of Klebsiella pneumonia

OBJECTIVE To approach the clinical infection characteristics and antimicrobial resistance of Klebsiella pneumonia(KPN)and seek management mode of rational use of antimicrobial agents to provide laboratory reference basis of improving the level of clinical physicians prescribing antibiotics and effective anti-infective chemotherapy.METHODS Strictly according to hospital clinical microbiology procedure issued by the ministry of health,specimen collection,inspection and inoculation,bacterial cultivation and isolation were performed by the routine methods.The susceptibility testing was performed for 387KPN isolates by K-B methods.The testing results were assessed by the newest breakpoints of CLSI.The WHONET 5.5software was used to adopt the data.RESULTS The 387strains of KPN were mostly from the respiratory tract and urinary tract samples,accounting for 54.8%and 15.0%,respectively.The 171isolates of ESBLs-producing KPN accounted for 44.2%.Resistance rate of sulfamethoxazole/trimethoprim was the highest,arriving at 63.3%.The antibiotics with more than 40%of resistance rate were cefotaxime,ceftriaxone,gentamycin,levofloxacin and ciprofloxacin.Those with less than10.0%included amikacin,cefoperazone/sulactam,piperacillin/tazobactam.100% of KPN was sensitive to carbapenems.CONCLUSION The antimicrobial resistance was inceasing in the grass-root hospital.Hospitals should strengthen implementing management of clinical application of antibiotics issued by the ministry of health and raise the level of clinical antibacterial drug prescription,to use the antibiotics rationally and reverse the unhealthy phenomenon of the disordered growth of bacterial resistance.