Distribution and drug resistance of klebsiella pneumoniae causing nosocomial infections

OBJECTIVE To investigate the distribution and drug-resistance of Klebsiella pneumoniae(KPN) in nosocomial infections to provide the scientific evidence for the clinical use of the antibiotics.METHODS The drug sensitive test was performed by broth microdilution test and the drug resistance was analyzed.RESULTS A total of 420 KPN strains were mainly isolated from intensive care unit(ICU),departments of respiratory medicine,general sugery,rehabilitation and neurology,and so on;the KPN strains were mainly isolated from sputum(about 49.5%).The sensitive rate of KPN to imipenem was 98.6%;the drug resistance rates of KPN to piperacillin/tazobactam,amoxicillin/clavulanic acid,cefoxitin,cefepime,ceftazidime,levofloxacin,aztreonam,gatifloxacin and gentamicin were 70.0%～89.0%;and the sensitive rates of KPN to Ticarcillin/clavulanic acid,tobramycin,ciprofloxacin,cefotaxime,ceftriaxone,cefazolin,ampicillin/sulbactam,cefuroxime,tetracycline,piperacillin,cefalotin,trimethoprim and nitrofurantoin were 30.0%～69.0%;the sensitive rate to ampicillin was 4.8%;the drug sensitivity tests of 24 kinds of antibiotics showed that the drug sensitive rates to 8 kinds of antibiotics were slightly increased,to 13 kinds of antibiotics were slightly decreased and the sensitive rates of KPN to 3 kinds of antibiotics were in a little more downtrend.CONCLUSION Drug resistance status of KPN is well controlled.The clinician should continue to use antibiotics rationally according to the results of drug susceptibility test.