Effects of Shenzhijiannao Capsule on ethology of memory impairment medol in mice

Objective To observe the effects of Shenzhijiannao Capsule on ethology of memory impairment medol in mice.Methods According to the scores of step down test,ICR mice were grouped with method of block randomization into control group,model group,western group,oversized large dose group,large dose group,medium dose group,small dose group,with 18 mice per group.After 7 days′drug administration,reproducibility memory impairment model was duplicated with 30% ethanol in gavage,consolidation of memory impairment model with 12.5 mg/mL Sodium nitrite,and acquired memory impairment model with 0.3 mg/mL Scopolamine.Then the latency and the number of electric shock as the evaluation were recorded in mouse passive avoidance test.Results In reproducibility memory impairment model,there were siginificant differences found on the atency and the number of electric shock in western group(Piracetam),large dose group,medium dose group and small dose group compared to model group(P 0.01).In consolidation of memory impairment model,there were siginificant differences found on the atency in western group(Anlishen),medium dose group compared to model group(P 0.05 or P 0.01).In acquired memory impairment model,there were siginificant differences found on the atency in large dose group,medium dose group,small dose group compared to control group(P 0.05 or P 0.01).Conclusion The medium dose of Shenzhijiannao Capsule has more stable therapy effects in improving results of learning and memory on reproducibility memory impairment model,acquired memory impairment model and consolidation of memory impairment model.