Effects of Shenzhijiannao Capsule on Cholinergic System of Memory Disorder Model Induced by Scopolamine in Mice

Objective To observe the effects of Shenzhijiannao capsule on neuroethology and cerebral cholinergic system of acquired memory disorder model in mice.Methods According to the scores of step down test,ICR mice were randomly divided into seven groups,including control group,model group,aricept group,oversized large-,large-,medium-,small-dose Shenzhijiannao capsule group,with 18 mice in each group.The treatment group was given corresponding drug respectively,and control group and model group were given NS.After 7 d administration,acquired memory disorder model was made with scopolamine subcutaneous injection in the dose of 4.5 mg/kg.Then,the latency and the number of electric shock in passive avoidance test were recorded.After that,the activity of acetylcholinesterase(AchE) and acetylcholine transferase(AchT) of the right side of mice brain were measured with colorimetry.Results In the aspect of neuroethology,large-dose group,medium-dose group,small-dose group had siginificant difference compared with control group(P0.05),but aricept group and oversized large-dose group had no difference.In the aspect of the activity of AchT,there was no difference between treatment groups and control group.In the aspect of the activity of AchE,except large-dose group,there was siginificant difference between treatment groups and control group(P0.05).Conclusion Shenzhijiannao capsule may depress the activity of AchE and increase the activity of AchT,and the medium does of which have more stable effect.