Effect of ursodeoxycholic and domperidone on bile-reflux gastritis

Objective:To evaluate the effect of ursodeoxycholic(UDCA) and domperidone in bile-reflux gastritis.Methods:45 patients with bile-reflux gastritis proven by gastroscopy were divided into 3 groups equally at random,which were treated with UDCA 250 mg one day;domperidone 10 mg three times a day and both drugs respectively.The severity of the symptoms including abdominal pain,abdominal distention,nausea and bile vomitus were investigated before and four weeks after treatment.Gastroscopy was also reexamined.Results:The severity of the symptoms in the three groups decreased greatly after treatment(P0.01).Average disappearance in a symptom were 8.6 days,7.9 days and 5.4 days.The difference in three groups was statistically significant (P0.05).The disappearance rate of intraastric bile-reflux in three groups were 81.8%,84.6%和92.9%.Conclusion:UDCA combined domperidone can decrease the intragastric bile reflux,and are effective in bile reflux gastriris.