Effect of different doses of tropisetron in postoperative nausea and vomiting

AIM: To study the analgesic effect of different doses of tropisetron in preventing postoperative nausea and vomiting.METHODS: ASA grade Ⅰ-Ⅱ score of 150 cases,which was admitted for elective thoracic surgery in our hospital from January 2005 to December 2010,were divided into A,B,C three groups,n=50,A group using the analgesia adding 5 mg tropisetron,B group using the analgesia with 10 mg tropisetron,C group using 0.9% saline,compared the postoperative nausea and vomiting efficacy and adverse drug reactions of three groups of patients.RESULTS:A,B groups had no significant efficacy differences in the prevention of postoperative nausea and vomiting,but were significantly better than C group,P0.05.The adverse reactions of A,B groups were significantly more than C Group,P0.05,but can be tolerated.P0.05.A,B groups of adverse reactions was significantly more than Group C,P0.05,but can be tolerated.CONCLUSION: The analgesic effects in preventing postoperative nausea and vomiting of 5 mg,10 mg tropisetron are more satisfied,and adverse reactions can be tolerated.