Effects of Tropisetron on Postoperative Nausea and Vomiting Related to Patient-controlled Intravenous Analgesia with Tramadol

Objective To investigate the effects of tropisetron on postoperative nausea and vomiting(PONV) related to patient-controlled intravenous analgesia(PCIA) with tramadol.Methods Three hundred patients experienced abdominal surgery were divided randomly into 3 groups,100 in each.Group A received 5 mg tropisetron to prevent PONV,Group B 10 mg tropisetron,Group C normal sodium(control group).PONV was observed within 24 h after operation.Results Groups A,B,C confronted with postoperative nausea(8,5,79 cases,respectively),and with vomiting(8,6,63,respectively).In Group A the number of patients gaining 0,1,2,3 scores of postoperative nausea degree were 92,3,3,2 respectively,in Group B 95,3,1,1,respectively,and in Group C 21,22,20,37,respectively.In Group A,the numbers of patients scored 0,1,2,3 of postoperative vomiting degree were 92,3,2,3,respectively;in Group B 94,2,2,6,respectively,and in Group C 37,28,22,13,respectively.There was not significant difference in incident and degree of nausea and vomiting between Groups A and B(P0.05),but Group C different from Groups A,B(P0.05).Conclusion Use of 5 mg or 10 mg tropisetron,which is superior to single use of tramadol in control of PONV caused by PCIA,is one of antiemetic approschs,economic,effective and worthy of popularization.