Clinical Analysis of L-ornithine-L-aspartate Treating Hepatic Encephalopathy

Objective To evaluate the clinical efficacy and safety of L-ornithine-L-aspartate treating the patients with hepatic encephalopathy.Methods Sixty patients with hepatic encephalopathy from April 2000to November 2009 were randomly divided into treatment group and control group with 30patients in each.The patients in the control group were treated with the routine therapy of arginine,while the ones in the treatment group were treated with L-ornithine-L-aspartate besides the routine therapy for one week injection(10.0g dissolved in 5%glucose 250mL by in-travenous infusion once daily),the liver function and mind change were observed in all patients at the onset and one week after treatment respectively.Results One week after the treatment,the liver function(ALT、AST)and mind change of patients differed statistically significantly from that before the treatment(P0.05).Conclusion L-ornithine-L-aspartate is effective for the patients with minimal hepatic encephalopathy,which could improve the liver function with little side effect.