Investigation of the correlation between bone mineral density and bone metabolism index in healthy adults in Jiaodong Peninsula

Objective To investigate the relationship between bone mineral density(BMD) and serum levels of bone metabolism index including tartrate-resistant acid phosphatase(TRAP-5b),collagen type I carboxy-terminal peptide(CTX),bone alkaline phosphatase(BALP),bone Gla protein(BGP),calcitonin(CT),and 25-OH-vitamin D(25-OH-D) in healthy adults in Jiaodong Peninsula of Shandong.Methods Using dual-energy X-ray absorptiometry(DEXA) equipment,BMD was measured among 436 normal people(207 men and 229 women,aged 21-89 years old) in Jiaodong peninsula with a multi-center,multi-staging sampling method.The bone metabolism index was measured using a ELISA analyzer(USA Thermo) and an automatic biochemical analyzer(HITACHI 7600-20).The 436 subjects were divided into different gender groups with each ten-year of age.SPSS 13.0 software was used for data analysis.Results The levels of TRAP-5b,CTX-1,BALP,and BGP were not significantly different between the two genders in the 21-49 year group.Those were different in the 50-89 year group,being higher in the female than in the male.TRAP-5b and CTX were negatively correlated with BMD.BALP and BGP increased in the 50-69 year group in females,and they were negatively correlated with BMD.The values decreased after 70 years old.25-OH-D was positively correlated with BMD.CT decreased in the 60-89 year age group,and it was positively correlated with BMD.Serum Ca and P were no significant difference.Conclusion The measurement of bone metabolism index provided a significant technical method for monitoring bone mass and early diagnosis of osteoporosis.The ratio of bone formation markers and bone resorption markers was different females of different age.Bone turnover increased in the postmenopausal women.