The correlation between biochemical markers of bone metabolism and bone mineral density in senile osteoporosis patients in Jiaodong Peninsula of Shandong

Objective To investigate the correlation between biochemical markers of bone metabolism and bone mineral density(BMD)in senile osteoporosis patients in Jiaodong Peninsula of Shandong and to explore the clinical value of biochemical markers of bone metabolism on the early diagnosis of primary osteoporosis.Methods BMD of the lumbar vertebrae 2-4 of 297 40-89 years old subjects in Jiaodong peninsula,sampled using the multi-center and multi-stage sampling method,was measured using dual energy X-ray absorptiometry(DEXA).Serum TRAP-5b,CTX,BALP,BGP,CT,25(OH) D,Ca,and P were detected using ELISA.SPSS 13.0 was used to analyze the data statistically.Results BMD of osteoporosis patients was significantly lower than that of the control patients.BMD and indexes of bone formation and absorption in senile males showed a decreasing trend.BGP,TRAP,and 25(OH) D in senile males in osteoporosis group were significantly lower than those in non-osteoporosis ones(P0.05).Serum CTX and BALP of senile males in the osteoporosis group were significantly higher than those in the non-osteoporosis group.Serum TRAP-5b,CTX,BALP,and BGP in females in osteoporosis group were significantly higher than those of the controls(P0.01).Serum CT and 25(OH) D were significantly lower than those of the controls.The differences of all biochemical markers of bone metabolism were statistically significant.Conclusion The serum biochemical indexes of bone metabolism can be used as the monitor index of OP.The application of these indexes is more sensitive and specific than BMD.It can reflect the bone metabolism in the early stage,and has great significance in the prevention and treatment osteoporosis.